Thermoresponsive Near-Infrared Absorbing Nanogels for Combinational Chemo- and Photothermal therapy of Cancer.

FECHNER; KAR; M.A. MOLINA; STEFANIE WEDEPOHL; MARCELO CALDERÓN

Conferencia; 6th International Colloids Conference; 2016

In this work, we developed a family of polymeric NIR absorbing nanogels, studied their physicochemical properties, and evaluated their biological applications. The biocompatible, thermoresponsive nanogels are made from hyperbranched polyglycerol as macromolecular cross-linker and thermoresponsive poly(N-isopropylacrylamide) or poly(N-isopropylmethacrylamide). NIR sensitivity was introduced to the thermoresponsive nanogels by semi-interpenetration with PANI or PPY through in situ polymerisation into the network of the nanogels (Figure 1). The physicochemical characterizations of the water-soluble composites were accomplished successfully. All sIPN NGs show a strong heating capacity upon NIR irradiation. The biological evaluations showed no cytotoxicity of the sIPN NGs itself, but strong effects on cell viability if illuminated with NIR.[4-5] In addition, first in vivo studies indicate a good tolerability of the NGs and show good antitumor efficiencies