Thermoresponsive nanogels based on hyperbranched polyglycerol for dermal protein delivery

M.A. MOLINA; MADELEINE WITTING; WOLFGANG FRIESS; SARAH KÜCHLER; MARCELO CALDERON

Chicago

Congreso; 41st Annual Meeting & Exposition of the Controlled Release Society; 2014

A thermoresponsive nanogel made of poly(N-isopropylacrylamide) and hyperbranched polyglycerol was made to encapsulate proteins, protect them, and trigger release in dermal applications. Efficient encapsulation in the nanogels and subsequent release of the proteins without loss of protein activity was achieved.