Thermo-responsive Nanogel Synthesis by Strain Promoted Azide Alkyne Cycloaddition

MICHAEL GIULBUDAGIAN; MAZDAK ASADIAN; DIRK STEINHILBER; KATHARINA ACHAZI; M.A. MOLINA; MARCELO CALDERON

Chicago

Congreso; 41st Annual Meeting & Exposition of the Controlled Release Society; 2014

We present a novel synthetic method of thermo-responsive all-glycerol nanogels (NG) based on hyperbranched polyglycerol (HPG) as a macro-cross-linker and linear poly(glycidyl methyl ether-co-ethyl glycidyl ether) (p(GMEco-EGE)) as a thermo-responsive polymer. The nanogels are synthesized by nanoprecipitation of the macro-monomers in water, followed by gelation of the precursor particles. The crosslinking points were generated by strain- promoted azide alkyne cycloaddition (SPAAC) of the prefunctionalized polymers. The mild reaction conditions which do not require the input of high energy, elevated temperature, or the presence of colloidal stabilizer promise the encapsulation of bioactives during nanogel synthesis. Moreover, their temperature triggered release is expected to be highly tunable and find applications in various fields.