Hyperbranched polyglycerol nanogels ? a new tool for dermal drug delivery?

MADELEINE WITTING ; DIRK STEINHILBER; MARIA MOLINA; MARCELO CALDERON; RAINER HAAG; WOLFGANG FRIESS; SARAH KÜCHLER

Congreso; 9TH WORLD MEETING on Pharmaceutics, Biopharmaceuticsand Pharmaceutical Technology; 2014

Therapeutically relevant proteins such as antibodies, growth factors or enzymes play an increasing role in the treatment of malignant and autoimmune diseases. However, they often suffer from insufficient stability and poor bioavailability. A suitable method to increase protein stability might be the non-covalent encapsulation into polyglycerol-based nanogels. For drug release, external stimuli such as pH or a thermal trigger can be used to initiate a controlled and targeted release [1]. By introducing an acid cleavable functional group as well as a thermosensitive cross-linker, two different types of hyperbranched polyglycerol (hPG)-nanogels were developed [1, 2, 3]. The model proteins bovine serum albumin (BSA), L-asparaginase and lysozyme were incorporated and drug release, protein stability and dermal drug delivery were investigated.