Fabrication of thermoresponsive nanogels by thermo-nanoprecipitation and in situ encapsulation of bioactives

MICHAEL GIULBUDAGIAN; MAZDAK ASADIAN; DIRK STEINHILBER; KATHARINA ACHAZI; M.A. MOLINA; MARCELO CALDERON

Polymer Chemistry

RSC

Año: 2014 vol. 5 p. 6909 - 6913

A synthetic method for thermoresponsive, glycerol based nanogelshas been developed. The nanogels were synthesized by nanoprecipitationof the orthogonally functionalized macromonomers andtheir gelation in water. The crosslinking points were generated bystrain promoted azide?alkyne cycloaddition which enabled thein situ encapsulation of Doxorubicin HCl. The mild and surfactantfree reaction conditions make these nanogels ideal candidates forbiomedical applications