INVESTIGADORES
GARELLI Fabricio
capítulos de libros
Título:
The ARG algorithm: clinical trials in Argentina.
Autor/es:
PATRICIO COLMEGNA; FABRICIO GARELLI; HERNÁN DE BATTISTA; FERNANDO D. BIANCHI; RICARDO SANCHEZ PEÑA
Libro:
The Artificial Pancreas: current situation and future directions
Editorial:
Elsevier
Referencias:
Año: 2019; p. 79 - 104
Resumen:
An Artificial Pancreas (AP) is a system to automatically regulate the glucose levelin Type 1 Diabetes Mellitus (T1DM), and reduce the constant burden of this diseaseas much as possible. Although several AP schemes exist [1, 2], here we considerthat only insulin is infused, and both measurement and infusion are performed subcutaneouslyvia a Continuous Glucose Monitoring (CGM) sensor, and an insulinpump. This represents a single-hormone scheme based on a minimally invasive APsystem that allows ambulatory use, but unfortunately, makes the control problemmuch harder.The main obstacles that have to be taken into account in designing AP controllersare:- lag-times and errors, both in glucose measurement and insulin action;- nonlinearities;- large inter? and intrapatient uncertainties; and- technical difficulties (sensor dropouts and insulin set failure).......
