Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas

MOSCOSO-VASQUEZ, MARCELA; COLMEGNA, PATRICIO; ROSALES, NICOLAS; GARELLI, FABRICIO; SANCHEZ-PENA, RICARDO

IEEE Journal of Biomedical and Health Informatics

IEEE

Año: 2020 p. 1 - 1

2168-2194

In this work, a low-order model designedfor glucose regulation in Type 1 Diabetes Mellitus(T1DM) is obtained from the UVA/Padova metabolicsimulator. It captures not only the nonlinear be-havior of the glucose-insulin system, but also intra-patient variations related to daily insulin sensitivity(SI) changes. To overcome the large inter-subject vari-ability, the model can also be personalized based on apriori patient information. The structure is amenablefor linear parameter varying (LPV) controller design,and represents the dynamics from the subcutaneousinsulin input to the subcutaneous glucose output. Theecacy of this model is evaluated in comparison witha previous control-oriented model which in turn isan improvement of previous models. Both models arecompared in terms of their open- and closed-loop dif-ferences with respect to the UVA/Padova model. Theproposed model outperforms previous T1DM control-oriented models, which could potentially lead to morerobust and reliable controllers for glycemia regulation.