INVESTIGADORES
GARELLI Fabricio
artículos
Título:
Analysis of Transcriptional Feedback Strategy for Reducing Interaction in Gene Expression Processes
Autor/es:
NUÑEZ, SEBASTIÁN; GARELLI, FABRICIO; PICÓ, JESÚS; BATTISTA, HERNÁN DE
Revista:
IFAC-PapersOnLine
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2019 vol. 52 p. 526 - 531
ISSN:
2405-8963
Resumen:
Advances in genetic manipulation have allowed the overexpression of proteins andinsertion of circuits in cells. However, the expected behaviour can be altered by the internalcompetition for the limited amount of cellular resources. In this work we analyse a feedbackstrategy based on transcription inhibition that aims to reduce the interaction in a two-proteinexpression system. The results allow interpreting the effects of negative feedback on the steadystateprotein levels and how the realizable protein region is affected by the feedback loop.
