Safety Auxiliary Feedback Element for the Artificial Pancreas in Type 1 Diabetes.

ANA REVERT; FABRICIO GARELLI; JESÚS PICO; HERNÁN DE BATTISTA; PAOLO ROSSETTI; JOSEP VEHÍ; JORGE BONDÍA

IEEE TRANSACTIONS ON BIO-MEDICAL ENGINEERING

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC

Lugar: New York; Año: 2013 vol. 60 p. 2113 - 2122

0018-9294

The artificial pancreas aims at the automatic delivery of insulin for glycemic control in patients with type 1 diabetes, i.e., closed-loop glucose control. One of the challenges of the artificial pancreas is to avoid controller over-reaction leading to hypoglycemia, especially in the late post prandial period. In this work, an original proposal based on sliding mode reference conditioning ideas is presented as a way to reduce hypoglycemia events induced by a closed-loop glucose controller. The method is inspired in the intuitive advantages of two-step constrained control algorithms. It acts on the glucose reference sent to the main controller, shaping it so as to avoid violating given constraints on the insulin-on-board. Some distinctive features of the proposed strategy are that (i) it provides a safety layer which can be adjusted according to medical criteria, (ii) it can be added to closed-loop controllers of any nature, (iii) it is robust against sensor failures and over-estimated prandial insulin doses, (iv) it can handle non-linear models. The method is evaluated in-silico with the 10 adult patients available in the FDA-accepted UVA simulator.