INVESTIGADORES
DAIER Veronica Andrea
artículos
Título:
Synthesis, Structure and SOD Activity of Mn Complexes With Symmetric Schiff Base Ligands Derived From Pyridoxal
Autor/es:
SIGNORELLA, SANDRA; DAIER, VERĂ“NICA; LEDESMA, GABRIELA; PALOPOLI CLAUDIA; BACK, DAVI; LANG; ERNESTO; ROSSINI, CRISTIELI; GIACOMELLI, CRISTIANO
Revista:
POLYHEDRON
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 102 p. 176 - 184
ISSN:
0277-5387
Resumen:
This study describes the synthesis, crystal structure and antioxidant activity of manganese(III) complexes with Schiff-base ligands obtained from condensation of pyridoxal with alkyl diamines: [Mn(pyr2en)(H2O)2]Cl?4H2O, [Mn(pyr2en)(H2O)(CH3OH)]Cl, [Mn(pyr2pn)(H2O)2]ClO4 and [Mn2(pyr2bn)3]?6H2O, where H2pyr2en = 1,2-bis(pyridoxylidenamino)ethane, H2pyr2pn = 1,3-bis(pyridoxylidenamino)propane and H2pyr2bn = 1,4-bis(pyridoxylidenamino)butane. The four complexes catalyze the dismutation of superoxide efficiently with IC50 values in the range of 1.22 to 2.15 M, evaluated through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The length of the alkyl spacer in the diamine fragment plays a key role in the antioxidant activity of these complexes, with [Mn(pyr2pn)(H2O)2]ClO4 showing the lowest IC50 value.