In vivo and in vitro inhibitory effecto of Dexamethasone on the thermogenic process of beige adipocites

GIORDANO ALEJANDRA PAULA; ZUBIRÍA, MARÍA GUILLERMINA; GAMBARO, SABRINA ELIANA; MARTIN FLORENCIA; MARIA AMANDA REY; SPINEDI, EDUARDO; GIOVAMBATTISTA, ANDRÉS

Mar del Plata

Congreso; LXIII Reunion Anual de la Sociedad Argentina de Investigacion Clínica; 2018

Glucocorticoids (GCs) modulate the biology and function of white and brown adipose tissue (AT); however, GCs effect on beige adipocytes activation remains unknown. We studied dexamethasone (DXM) effects on the thermogenic activity of beige adipocytes from Retroperitoneal AT (RPAT). Male rats were divided into four groups: control (CTR) and DXM injected (sc 0,03mg/Kg/d for 7 days, DXM) and housed at room temperature, and CTR and DXM housed under cold stimulus (4°C for 7 days, CTR-C and DXM-C, respectively). RPAT pads were dissected, weighted and processed for UCP-1 and PGC1⍺ quantification (RT-PCR). Both, DXM and cold exposure decreased RPAT mass/100 gr body weight (P