PREDICTION OF GPI ANCHORED PROTEINS OF Cryptosporidium parvum: POTENCIAL VACCINE AND DIAGNOSTIC CANDIDATES

MARIELA L. TOMAZIC; ANABEL E. RODRIGUEZ; ALEJANDRO D. NUSBLAT; CLARA B. NUDEL; MÓNICA FLORIN-CHRISTENSEN; LEONHARD SCHNITTGER

Campinas

Otro; Structural and Function of Membrane Proteins Course; 2012

Centro Nacional de Pesquisa em Energia e Materiais

Cryptosporidiosis is a zoonotic desease mainly caused by the apicomplexa protozoo Cryptosporidium parvum. It is considered a transcendent desease in developing countries and emergent in industrialized countries. Nowadays, neither efective treatment nor proper control measurements are available. Thus, the identification of surface antigens and their subsequent expression may serve as components of subunits vaccine as well as of diagnostic tools, confering efective protection or improving prevention and infection disemination. Glycosylphosphatidylinositol (GPI) anchored proteins are involved in invasive stages of many protozoa parasites and are immunodominants; therefore, they are vaccine and diagnostic potential candidates