INVESTIGADORES
ROLDAN OLARTE Eugenia Mariela
congresos y reuniones científicas
Título:
Type I and Type II BMP Receptor Expression and Signaling in Bovine Oviduct Epithelial Cell
Autor/es:
VALDECANTOS, PA.; BRAVO MIANA, ROCÍO DEL CARMEN; GARCÍA, D.C; GARCÍA, EV; DORA C. MICELI; MARIELA ROLDÁN OLARTE
Lugar:
Mar del Plata
Reunión:
Congreso; 51 Annual Meeting Argentine Society for Biochemistry and Molecular Biology; 2015
Institución organizadora:
Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Resumen:
Members of the transforming growth factor beta (TGF-β) family, including the bone morphogenetic proteins (BMPs) are expressed in the mammalian oviduct Epithelial cells. These signaling molecules play important roles in development and tissues homeostasis; little is known about their function in the oviduct. Modulation of TGF-β/BMP receptor activity is a critical step for signaling Regulation. In the present study, RT-qPCR was used to analyze mRNA expression of BMP receptors type I (BMPR1A, BMPR1B, ACVR1, ACVR1L) and type II (BMPR2, ACVR2A,ACVR2B) in bovine oviduct epithelial cells (BOEC) isolated from ampulla and isthmus at proestrous and diestrous (n=3). Results were statistically analyzed by Student t-test. All of the mRNA BMP receptors were detected in BOEC, except ACVRL1. During diestrous, higher significant mRNA levels were found for BMPR1B, BMPR2 and ACVR2B in isthmus BOEC; and for ACVR2 mRNA in ampulla epithelial cells (p