Complexation between doxycycline hyclate and b-cyclodextrin. Experimental and theoretical studies

KOGAWA, A.C.; ZOPPI, A.; QUEVEDO, M.A.; NUNES SALGADO, H.R.; LONGHI, M.R.

Riberão Preto

Congreso; 8th International Congress of Pharmaceutical Sciences; 2011

Comité Organizador del 8vo. Congreso Internacional de Ciencias Farmacéuticas

Doxycycline (DOX) is a drug effective against a large variety of bacteria. In addition, it hasantiprotozoal actions and may be administered in conjunction with quinine in the managementof falciparum malaria. Unfortunately DOX is quite susceptible to light, thus diverse strategiestowards increasing its photostability are envisioned. A commonly applied approach toincrease the stability of drugs is the formation of complexes with macromolecules, of whichmolecular encapsulation with β-cyclodextrin (βCD) constitutes an alternative for thedevelopment of new pharmaceutical dosage forms. The objective of this work was toinvestigate the possibility of obtaining an inclusion complex between DOX and βCD inorder to enhance this drug stability, by combining both experimental and theoreticalapproaches.