Insights into vertebrate head development: from cranial neural crest to the modelling of neurocristopathies

WEINER, ANDREA; COUX, G.; ARMAS PABLO; CALCATERRA NB

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

U B C PRESS

Lugar: Bilbao; Año: 2020

0214-6282

Although the vertebrate head has evolved to a widecollection of adaptive shapes, the fundamental signalling pathways and cellularevents that outline the head skeleton have proven to be highly conserved. Thisconservation suggests that major morphological differences are due to changesin differentiation and morphogenetic programs downstream of a well-maintaineddevelopmental prepattern. Here we provide a brief examinationof the mechanisms and pathways responsible for vertebrate head development. We alsopresent an overview of the animal models suitable for studying facedevelopment. Finally, we describe the criteria for the classification of neurocristopathies,highlighting the contribution of zebrafish to the modelling of Treacher Collins/Franceschetti Syndrome, an emblematicneurocristopathy.