Biological and structural characterization of two novel membrane-active peptides isolated from the skin of Leptodactylus latrans and Hypsiboas pulchellus

SIANO, ALVARO; GATTI, PAULA; SIMONETTA, ARTURO; LAJMANOVICH, RAFAEL; TONARELLI, GEORGINA

Rosario

Congreso; II Reunión Internacional de Ciencias Farmacéuticas (RICIFA); 2012

The emergence of bacterial strains resistant to conventional antibiotics is one of the major causes of inefficient therapy and high mortality rates. For this reason, intensive efforts are being made to develop novel drugs targeting bacterial cell membranes. Antimicrobial peptides are prevalent in nature as part of the intrinsic defense mechanism of most organisms (1). The aim of this study was to explore the biological and conformational properties of two novel peptide sequences identified by LC-MS-MS from the skins of Leptodactylus latrans (Ll) and Hypsiboas pulchellus (Hp).