INVESTIGADORES
SIANO Alvaro Sebastian
congresos y reuniones científicas
Título:
Synthetic bacteriocin analogs as therapeutics peptides, effects of fatty acid conjugation on their antimicrobial properties
Autor/es:
HUMPOLA, MARÍA VERONICA; SPONTON, PABLO; SIANO, ALVARO; REY, CAROLINA; SIMONETTA, ARTURO; TONARELLI, GEORGINA
Lugar:
Cordoba
Reunión:
Encuentro; 1ª Reunión Internacional de Ciencias Farmacéuticas.; 2010
Resumen:
The increasing bacterial resistance against conventional antibiotics has led to the search for new antimicrobial drugs with different modes of action. Cationic antimicrobial peptides (AMPs) are promising candidates to treat infections since they act on bacterial membranes causing rapid destruction of sensitive bacteria. Previous studies have demmonstrated that conjugation of AMP with saturated fatty acids increased their antimicrobial propertie.Plantaricin 149a (YSLQMGATAIKQVKKLFKKKGG), CT (GATAIKQVKKLFKKKGG), CTc (IKQVKKLFKK), and N- terminal fatty acid conjugated analogs C8-CT, C12-CT and C8-CTc, were synthesized by Fmoc-SPPS as C-terminal carboxamides.Pln149a and CT exhibits the lowest antimicrobial activity against S. aureus strain.
