Selective Formation of Porous Pt Nanorods for Highly Electrochemically Efficient Neural Electrode Interfaces

GANJI, MEHRAN; PAULK, ANGELIQUE C.; YANG, JIMMY C.; VAHIDI, NASIM W.; LEE, SANG HEON; LIU, REN; HOSSAIN, LORRAINE; ARNEODO, EZEQUIEL M.; THUNEMANN, MARTIN; SHIGYO, MICHIKO; TANAKA, ATSUNORI; RYU, SANG BAEK; LEE, SEUNG WOO; TCHOE, YOUNGBIN; MARSALA, MARTIN; DEVOR, ANNA; CLEARY, DANIEL R.; MARTIN, JOEL R.; OH, HONGSEOK; GILJA, VIKASH; GENTNER, TIMOTHY Q.; FRIED, SHELLEY I.; HALGREN, ERIC; CASH, SYDNEY S.; DAYEH, SHADI A.

NANO LETTERS (PRINT)

AMER CHEMICAL SOC

Año: 2019 vol. 19 p. 6244 - 6254

1530-6984

The enhanced electrochemical activity of nanostructured materials is readily exploited in energy devices, but their utility in scalable and human-compatible implantable neural interfaces can significantly advance the performance of clinical and research electrodes. We utilize low-temperature selective dealloying to develop scalable and biocompatible one-dimensional platinum nanorod (PtNR) arrays that exhibit superb electrochemical properties at various length scales, stability, and biocompatibility for high performance neurotechnologies. PtNR arrays record brain activity with cellular resolution from the cortical surfaces in birds and nonhuman primates. Significantly, strong modulation of surface recorded single unit activity by auditory stimuli is demonstrated in European Starling birds as well as the modulation of local field potentials in the visual cortex by light stimuli in a nonhuman primate and responses to electrical stimulation in mice. PtNRs record behaviorally and physiologically relevant neuronal dynamics from the surface of the brain with high spatiotemporal resolution, which paves the way for less invasive brain-machine interfaces.