Effect of exogenously applied polyamines on malathion toxicity in the toad Bufo arenarum Hensel

VENTURINO A; GAUNA L.E; BERGOC R.M.; PECHEN DE D’ANGELO A.M.

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

SPRINGER

Lugar: Berlin; Año: 1992 vol. 22 p. 135 - 139

0090-4341

The polyamines putrescine, spermidine and spermine, are able to potentiate the toxicity of malathion in Bufo arenarum Hensel toad larvae. This action is synergistic and maximal with spermidine, which elevated up to 13-fold the mortality produced by this organophosphorus compound, Spermidine increased the degree of inhibition of acetylcholinesterase activity elicited by malathion, and impaired the recovery of this activity at the end of the treatment. Spermidine had no effect on the enzyme when applied at concentrations similar to the intracellular levels described for rapid-growing organisms.