EXOSOMES ISOLATED FROM ASCITES OF T-CELL LYMPHOMA-BEARING MICE INDUCE A TUMOR-SPECIFIC IMMUNE RESPONSE

FLORENCIA MENAY; FEDERICO COCOZZA; RODRIGO TSACALIAN; ANALIA ELISEI; LETICIA HERSCHLIK; JULIETA DE TORO; MARÍA JOSÉ GRAVISACO; MARÍA PAULA DI SCIULLO; ALEJANDRINA VENDRELL; CLAUDIA WALDNER; CLAUDIA MONGINI

Buenos Aires

Congreso; Reunion Conjunta de Sociedades de Biociencias; 2017

Exosomes are endosome-derived nanovesicles involved in cell?cell communication. Tumor exosomes can either activate or inhibit the immune system. The neoplastic stage and microenvironment can affect the quantity and composition of EVs determining their biological behavior. In this work, we have evaluated the ability of exosomes isolated from ascites of a murine T-cell lymphoma (ExoA) to modulate a tumor-specific immune response. ExoA induced in vitro proliferation of tumor sensitized splenocytes when compared with unstimulated control (p