Chronic Stress-Induced Changes in Locus Coeruleus Neuronal Activity

LUIS A. PAVCOVICH, LILIANA M. CANCELA, MARTA VOLOSIN,

BRAIN RESEARCH BULLETIN

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1990 vol. 24 p. 293 - 296

0361-9230

PAVCOVICH, L. A., L. M. CANCELA, M. VOLOSIN, V. A. MOLINA AND 0. A. RAMIREZ. Chronic stress-induced changes in locus coeruleus neuronal activity. BRAIN RES BULL 24(2) 293-296, 1990.-Locus coeruleus (LC) activity was assessed in rats exposed to either acute or chronic stress. After one immobilization session, the number of spontaneously active LC neurons dramatically decreased. On the other hand, repeated restraint sessions enhanced noradrenergic (NA) transmission and the inhibitory effect of clonidine (CLON) was greater on these cells than in those of controls. These results bear on the adaptive changes in the NA system following acute or chronic stress.Chronic stress-induced changes in locus coeruleus neuronal activity. BRAIN RES BULL 24(2) 293-296, 1990.-Locus coeruleus (LC) activity was assessed in rats exposed to either acute or chronic stress. After one immobilization session, the number of spontaneously active LC neurons dramatically decreased. On the other hand, repeated restraint sessions enhanced noradrenergic (NA) transmission and the inhibitory effect of clonidine (CLON) was greater on these cells than in those of controls. These results bear on the adaptive changes in the NA system following acute or chronic stress.BRAIN RES BULL 24(2) 293-296, 1990.-Locus coeruleus (LC) activity was assessed in rats exposed to either acute or chronic stress. After one immobilization session, the number of spontaneously active LC neurons dramatically decreased. On the other hand, repeated restraint sessions enhanced noradrenergic (NA) transmission and the inhibitory effect of clonidine (CLON) was greater on these cells than in those of controls. These results bear on the adaptive changes in the NA system following acute or chronic stress.(CLON) was greater on these cells than in those of controls. These results bear on the adaptive changes in the NA system following acute or chronic stress.