La expresión génica hipotalámica de la enzima citocromo P450scc en ratas hembras

GIULIANI, F.2,; YUNES, R. 1,2; CABRERA, R. 2,3

Revista Médica Universitaria

Facultad de Ciencias Médicas. Universidad Nacional de Cuyo

Lugar: Mendoza; Año: 2009 vol. 5 p. 29 - 46

1669-8991

Neurosteroids are extremely potent modulatory molecules synthesized in the central nervous system (CNS), whose activity is limited to that ambit. Several types on enzimatic molecules participate of their synthesis, like enzymes related to the cytochrome P450 (CP450) and others not vinculated to this group. In this paper we study the gene expression of CP450scc in the mediobasal hypothalamus (MBH) of female rats under differents hormonal condition, and its eventual relationship with estrogen and progesterone regulation of that expression. Evidence is presented regarding differential gene expression of CP450scc in the MBH, as well as evidence related to its positive regulation by estrogen and negative regulation by progesterone.