Alpha and beta noradrenergic mediation of NMDA glutamatergic effects on lordosis behaviour and plasmatic LH concentration in teh primed female rat.

LANDA AI; GARGIULO AJ; GARGIULO MM; CABRERA RJ.; BREGONZIO, C.; LAFUENTE SÁNCHEZ JV.; GARGIULO PA.

JOURNAL OF NEURAL TRANSMISSION. GENERAL SECTION.

Springer Wien

Año: 2009 vol. 116 p. 551 - 557

0300-9564

Abstract In previous studies we have found that blockade of NMDA (N-Methyl-D-Aspartic-Acid)-type glutamatergic receptor with intracerebroventricular (ICV) selective drugs induces an inhibition of lordosis in ovariectomized (OVX) estrogen primed rats receiving progesterone or luteinizing hormone releasing hormone (LHRH). By the opposite way, stimulation with NMDA in OVX estrogen primed rats induced a significant increase of lordosis. In the present study the action of an a1-noradrenergic antagonist, HEAT (BE 2254/2-beta-4-Hydroxyphenyl-Ethyl-Aminomethyl- 1-Tetralone), and Metoprolol, a b-noradrenergic antagonist, were studied injecting them ICV previously to NMDA administration in treated OVX estrogen primed rats. In experiment 1, the enhancing effect on lordosis induced by NMDA at high dose (1 lg) was abolished by HEAT administration (P