INVESTIGADORES
CABRERA KREIKER Ricardo Jorge
artículos
Título:
The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats
Autor/es:
MYRIAM R. LACONI; GUILLERMO CASTELLER; PASCUAL A. GARGIULO; CLAUDIA BREGONZIO; RICARDO J. CABRERA
Revista:
EUROPEAN JOURNAL OF PHARMACOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2001 vol. 417 p. 111 - 116
ISSN:
0014-2999
Resumen:
AbstractThe behavioural display in the plus-maze, an established experimental model of anxiety, was studied in rats injected into the lateral brain ventricle i.c.v.. with the neurosteroid 3a-hydroxy-5a-pregnan-20-one allopregnanolone.. Female rats under different gonadal hormonal status were chosen. Allopregnanolone enhanced exploration of the open arms in both estrous rats and ovariectomized estrogen and progesterone primed rats. No effect was observed in diestrous 1 and ovariectomized not-primed rats. In all cases, the plus-maze locomotor-exploratory behaviour was not affected by allopregnanolone. The GABAA receptor antagonist, bicuculline 9.8 mM i.c.v..reversed the allopregnanolone action in the ovariectomized primed rats. When bicuculline was injected i.c.v. in conjunction with allopregnanolone, the anxiogenic effect of bicuculline was reversed by the highest dose of 25 mM. of allopregnanolone only. These results suggest that allopregnanolone exerts an anxiolytic action interacting with the GABAA receptor in an estrogen-dependent manner. 2001.Elsevier Science B.V. All rights reserved.
