Hexachlorobenzene promotes angiogenesis in vivo, in a breast cancer model and neovasculogenesis in vitro, in the human endothelial cell line HMEC-1

PONTILLO CA; ALEJANDRO ESPAÑOL; CHIAPPINI FLORENCIA; NOELIA MIRET; COCCA CLAUDIA; ALVAREZ, LAURA; KLEIMAN DE PISAREV D; MARÍA ELENA SALES; ANDREA RANDI

Congreso; 50th Congress of the European Societies of Toxicology EUROTOX; 2014

Exposure to environmental pollutants may alter proangiogenic ability and promotes tumor growth. Hexachlorobenzene (HCB) is an organochlorine pesticide found in maternal milk and it is a ligand of the aryl hydrocarbon receptor (AhR). We demonstrated that HCB induces proliferation, migration and invasion in human breast cancer cells, as well as tumor growth and metastasis in vivo. Here, we examined the HCB action on breast cancer angiogenesis. We observed that HCB (3 and 30 mg/kg body weight) stimulates angiogenesis (42%,p