Proteolysis at the Archaeal Membrane: Advances on the Biological Function and Natural Targets of Membrane-Localized Proteases in Haloferax volcanii

DE CASTRO R.E.; GIMÉNEZ, M.I; CERLETTI, M.; PAGGI, R. A.; COSTA, M.I.

Frontiers in Microbiology

Frontiers

Lugar: Laussane; Año: 2022 vol. 13

Proteolysis plays a fundamental role in many processes that occur within the cellularmembrane including protein quality control, protein export, cell signaling, biogenesis ofthe cell envelope among others. Archaea are a distinct and physiologically diverse groupof prokaryotes found in all kinds of habitats, from the human and plant microbiomes tothose with extreme salt concentration, pH and/or temperatures. Thus, these organismsprovide an excellent opportunity to extend our current understanding on the biologicalfunctions that proteases exert in cell physiology including the adaptation to hostileenvironments. This revision describes the advances that were made on archaealmembrane proteases with regard to their biological function and potential natural targetsfocusing on the model haloarchaeon Haloferax volcanii.