EFECTS OF ALBENDAZOLE AND TRICLABENDAZOLE ON THE TESTICULAR MORPHOLOGY OF RATS WISTAR.

ALZOLA, R.; FELIPE, A.; SCARCELLA, S.; SOLANA, H.

Buenos Aires

Congreso; XXXIX Reunion Anual de la Asociación Argentina de Farmacología Experimental; 2007

Sociedad Argentina de Farmacologia Experimental (SAFE)

Albendazole (ABZ) and Triclabendazole (TCBZ) are benzimidazole antihelmíntics used in human and veterinary medicine. Its mechanism of action consists in the despolimerization of cytoplasmatic microtubules (MT) of the parasite. The MT in the host are important in the spermatogenesis and is possible its alteration by the action of these drugs. In this work were determined the effects of ABZ or TCBZ in the probable modifications of the rat testis morphology. Three groups of sexually mature Wistar rats were used. ABZ and TCBZ were administered orally in a dose of 2 g/Kg of body weight and to the group control an equivalent amount of sterile physiological solution. The organs were extracted to 48 h. post-treatment. Samples were processed by routine techniques until embedded in Histoplast. For the morphologic analysis of the testicular architecture, 5 mm slices were stained with hematoxilin and eosin. The average diameter of the sperm ducts was determined and it evaluated the histological appearance and height of his epithelial. ABZ caused a significant diminution of the tubular diameter with a 23.6% of altered tubules, absence of spermatozoa, partial loss of the spermatogenic line and appearance of membranous vacuoles between the cells of Sertoli. For the case of TCBZ histologics alterations were not observed. This work shows that ABZ, at the highest dose rate, affect the spermatogenetic function in mouse..