INVESTIGADORES
BECKWITH Esteban Javier
artículos
Título:
Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks
Autor/es:
BECKWITH, ESTEBAN J; YANOVSKY, MARCELO J
Revista:
CURRENT OPINION IN GENETICS & DEVELOPMENT.
Editorial:
CURRENT BIOLOGY LTD
Referencias:
Lugar: Londres; Año: 2014 vol. 27 p. 35 - 42
ISSN:
0959-437X
Resumen:
Gene expression programs activated in response to, or inanticipation of, environmental changes involve sequentialsteps, from transcription and RNA processing to nuclear exportand translation. Here we review recent advances in ourunderstanding of the multiple regulatory layers that control theoscillations in gene expression associated with daily rhythms inmetabolism and physiology across eukaryotic organisms.Whereas many genes show coordinated oscillations intranscription, RNA processing and translation, others showsignificant temporal disconnections between these processes.Thus, circadian oscillations constitute an ideal system forexamining how multiple transcriptional and post-transcriptionalregulatory steps are integrated to maximize organismaladjustments to environmental conditions.
