Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway

BECKWITH, ESTEBAN J; EZEQUIE AXEL GOROSTIZA; J. BERNI; CAROLINA REZÁVAL; AGUSTÍN PÉREZ-SANTÁNGELO; NADRA, ALEJANDRO DANIEL; CERIANI, M FERNANDA

PLOS BIOLOGY

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2013

1544-9173

Living organisms use biological clocks to maintain their internal temporal order and anticipate daily environmental changes. In Drosophila, circadian regulation of locomotor behavior is controlled by ~150 neurons; among them, neurons expressing the PIGMENT DISPERSING FACTOR (PDF) set the period of locomotor behavior under free-running conditions. To date, it remains unclear how individual circadian clusters integrate their activity to assemble a distinctive behavioral output. Here we show that the BONE MORPHOGENETIC PROTEIN (BMP) signaling pathway plays a crucial role in setting the circadian period in PDF neurons in the adult brain. Acute deregulation of BMP signaling causes period lengthening through regulation of dClock transcription, providing evidence for a novel function of this pathway in the adult brain. We propose that coherence in the circadian network arises from integration in PDF neurons of both the pace of the cell-autonomous molecular clock and information derived from circadian-relevant neurons through release of BMP ligands.