Effect of a maternal diet enriched in extra virgin olive oil on proinflammatory markers and lipid profile in cord blood from GDM pregnancies

DALMIRO GOMEZ RIBOT, ESTEBAN DÍAZ, MARÍA VICTORIA FAZIO, HEBE LORENA GÓMEZ, CARLOS GRESTA, EVANGELINA CAPOBIANCO, ALICIA JAWERBAUM

Congreso; Reunión anual de Sociedades Biocientíficas (SAIC 2021); 2021

Objectives: Gestational diabetes mellitus (GDM) is a prevalent disease that increases the risk of maternal and fetal complications. Previously, we found that amaternal enriched in extra virgin olive oil (EVOO) reduced the levels of several proinflammatory markers and triglycerides (TG) in maternal blood from GDM pregnancies. Here, our aim was to determine ifthe proinflammatory markers interleukin 6 (IL-6) and inducible nitric oxide synthase (iNOS), as well as lipid profile and the lipid chaperone Fatty Acid Binding Protein 4 (FABP4) levels are altered in umbilical cord blood obtained at term from pregnancies with GDM treated or not with a diet enriched in EVOO.Methods: Fifty healthy (Control) and GDM patients were enrolled (protocol approved by Hospital Pirovano Ethics Committee) and advised to follow the WHO diet for pregnancy. GDM patients were randomized to receive or not 36 g/day of EVOO from week 24-28 of gestation until delivery. At delivery, cord blood was obtained to evaluateiNOS, IL-6 and FABP4 levels (Western blot), and TG, Total and HDL-Cholesterol (TC, HDL-C; colorimetric assay).Results: Neither IL-6 nor iNOS were altered in the three evaluated groups compared to the control group, and were not affected by the diet enriched in EVOO.TG and HDL-C levels were decreased in umbilical cord blood from the GDM group compared to controls (25%, 7%respectively, p