Paternal programming of metabolic alterations in the placenta

DAIANA, M. FLORENCIA HEINECKE, ALICIA JAWERBAUM, EVANGELINA CAPOBIANCO.

Simposio; III Simposio Colombiano de placenta e Interacción materno-fetal 2020; 2020

The contribution of paternal diabetes to long-term offspring´smetabolic health is little known1.The aim was to evaluate the regulation of lipidmetabolism in the placenta of male fetuses (F2) from healthy pregnant rats thatwere mated with male diabetic rats (F1).Control (C) and type 2 diabetic male rats (D, diabetesobtained by intrauterine programming, glycemia 140-190 mg/dL)1-3 were matedwith control female rats. On day 21 of gestation, the pregnant and male ratswere euthanized. The placentas, the fetuses and fetal and paternal plasma wereobtained for further evaluation. In the paternal and fetal plasma of D rats, the levelsof triglycerides and cholesterol were increased (p<0.05 vs C). Fetal weightwas increased in D group (p<0.05), and placental weight was similar in bothgroups. The levels of triglycerides, cholesterol and free fatty acids wereincreased (p<0.05 vs C) in the placenta of D group. The mRNA levels ofPparalpha and its co-activator Pgc1alpha, and the mRNA levels of Fatp1 and Lipgwere increased in the placenta of D group (p<0.05 vs C).Paternal diabetes programs alterations in thefeto-placental lipid metabolism. The intergenerational transmission of thesemetabolic alterations may lead to adverse consequences to the adultoffspring.