Brain mapping of three somatostatin-encoding genes in the goldfish

CANOSA LF; CERDÁ-REVERTER JM; PETER RE

JOURNAL OF COMPARATIVE NEUROLOGY

Año: 2004 vol. 474 p. 43 - 57

0021-9967

In the present study the brain distribution of three somatostatin (SRIF)-encoding genes,PSS-I, PSS-II, and PSS-III, was analyzed by in situ hybridization (ISH) in the goldfish. ThePSS-I mRNA showed the widest distribution throughout the brain, whereas PSS-II transcriptswere restricted to some hypothalamic nuclei. On the other hand, PSS-III presents anintermediate distribution pattern. All SRIF encoding genes are expressed in hypophysiotropicnuclei supporting the idea that, in addition to SRIF-14, [Pro2] SRIF-14, and gSRIF-28have pituitary-controlling functions. Moreover, each of the genes is expressed in nucleidirectly associated with feeding behavior, suggesting a role for SRIF peptides in the centralcontrol of food intake and energy balance. Alternatively, they might have a role in processingsensory information related with feeding behavior, since PSS genes are expressed in the maingustatory, olfactory, and visual centers, which project to the hypothalamic feeding center inteleost fish