Singularities on the physicochemical properties of spontaneous AOT-BHD unilamellar vesicles in comparison with DOPC vesicles.

CRISTIAN C. VILLA; N. MARIANO CORREA; JUANA J. SILBER; FERNANDO MOYANO; R. DARÍO FALCONE

PHYSICAL CHEMISTRY CHEMICAL PHYSICS

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2015 vol. 17 p. 17112 - 17121

1463-9076

In the present work we study different physicochemical properties of the spontaneous unilamellar vesicles created by the catanionic ionic liquids-like surfactant benzyl-n-hexadecyldimethylammonium 1,4-bis-2-ethylhexylsulfosuccinate (AOT-BHD), using two different fluorescent probes: 6-propionyl-2-(dimethylaminonaphthalene), PRODAN and trans-4-[4-(dimethylamino)-styryl]-1-methylpyridinium iodide, HC. Steady-state and time resolved fluorescence emission spectroscopy allowed us to find unique properties on the AOT-BHD bilayer in comparison with vesicles formed with the traditional phospholipid 1,2-dioleoyl-sn-glycero-3-phosphocholine, DOPC. From the emission results, we observed that the region of the bilayer close to the polar head of AOT-BHD is a powerful electron donor environment, even larger than DOPC. Additionally, the AOT-BHD bilayer offers a less polar and slightly more viscous zone than the DOPC one. Thus, this particular bilayer is able to produce large incorporation of ionic and nonionic molecules and is very promising to be used as nanocarrier in pharmacologic, cosmetic and foods fields.