INVESTIGADORES
RIVEIRA Martin Jorge
artículos
Título:
Multicomponent Domino Synthesis of Cyclopenta[b]furan-2-ones
Autor/es:
RIVEIRA, M. J.; MARCARINO, M. O.; LA-VENIA, A.
Revista:
ORGANIC LETTERS
Editorial:
AMER CHEMICAL SOC
Referencias:
Año: 2018 vol. 20 p. 4000 - 4004
ISSN:
1523-7060
Resumen:
A stereoselective multicomponent reaction involving Meldrum?s acid, a conjugated dienal, and an alcohol is reported. Valuable cyclopenta[b]furan-2-ones are obtained as products of this straightforward transformation, which is accompanied by the formation of four stereocenters, two new cycles, and four new bonds (two C−C and two C−heteroatom). A reaction mechanism was elaborated involving an initial Knoevenagel condensation followed by cycloisomerization and eventual fragmentation.
