INVESTIGADORES
RIVEIRA Martin Jorge
artículos
Título:
Pericyclic Cascade toward Isochromenes: Application to the Synthesis of Alkaloid Benzosimuline
Autor/es:
RIVEIRA, M. J.; LA-VENIA, A.; MISCHNE, M. P.
Revista:
JOURNAL OF ORGANIC CHEMISTRY
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2016 vol. 81 p. 7977 - 7983
ISSN:
0022-3263
Resumen:
The synthesis of biologically active alkaloid benzosimuline, isolated from the shrub Zanthoxylum simulans, is reported. Key transformation involves an oxa-6ð electrocyclic ring opening/hetero-Diels−Alder pericyclic cascade. Although the last aromatization step proved to be cumbersome, this work unfolds a unique route to access interesting molecules from simple precursors.
