Effect of cold environment on hepatic microsomal D6 and D9 desaturases activity of male rats

VES-LOSADA, ANA; PELUFFO RAÚL O.

LIPIDS

Ed. AOCS Press

Año: 1987 vol. 22 p. 583 - 588

0024-4201

Male rats maintained at 24 C and then shifted to 5 C for 5 days increased food intake and decreased in growth rate and food conversion. No modification was observed in D6 desaturase activity, while D9 desaturase activity decreased after this period of time. These results were confirmed by liver microsomal and mitochondriai fatty acid composition. The phospholipid composition of liver microsomes was unaltered, whereas in mitochondria, phosphatidylcholine and sphingomyelin decreased and phosphatidylethanolamine increased due to the cold environment. The influence of food intake and weight changes on fatty acid metabolism was studied using (i) rats maintained at 5 C with restricted food intake to match the food intake of those kept at 24 C with food ad libitum and (ii) rats maintained at 24 C whose food intake was also restricted so that their growth rate would be the same as that of rats maintained at 5 C with food ad libitum, respectively. These results indicate that the negative metabolic balance state of these cold conditions is not an active factor modifier of D6 desaturase activity, whereas it decreases D9 desaturase activity, reflecting the lipogenic characteristics of the latter enzyme. Lipids 22, 583-588 (1987).