"Lab-on-a-Tip: Reversible adsortive foams for protein and DNA purification."

MIRNA LORENA SANCHEZ; MARCELO FERNANDEZ LAHORE; MARIANO GRASSELLI

Beijing

Congreso; 17th International Biophysics Congress; 2011

IUPAB

Modern biotechnology heavily depends on the availability of efficient processes, which should be able to generate competitive products. Recovery and purification of bioproducts is mainly based on chromatographic separations. However, the low productivity imposed by diffusional limitations, the need for multiple chromatographic steps, and the requirement of extensive solid separation, drives to a technological situation characterised by low global product yields. Disposable products reduce the process development and costly validation protocols. Our strategy is combine direct product separation and disposable materials. The aim of this work is to develop novel chromatographic supports based on synthetic foams for protein capture from non-clarified feedstocks.