Fine tuning VBM for mouse brain analysis: model adjustment using atrophy simulation

BRAGGIO, D; BARBEITO - ANDRÉS, J; GONZALEZ, PN; LARRABIDE, I

Simposio; 14th International Symposium on Medical Information Processing and Analysis; 2018

Voxel-based morphometry (VBM) is a technique used todetect and localize morphological differences in brain anatomy. Its designincludes the adjustment of several parameters that infuence  results, including the spatial normalizationmethod used during preprocessing. VBM is widely applied in human studies, yetits usage for experimental animal models is scarce in the literature. Moreover,there is no a quantitative analysis nor validation of the method's results whenapplied to small animal brain images. In this work we evaluated results of different VBMworkflows by simulating tissue changes on the mouse brain.