INVESTIGADORES
APARICIO Juan Pablo
congresos y reuniones científicas
Título:
Twenty years of Leishmaniasis dynamics in northwest Argentina: Time-series analysis and mathematical modeling
Autor/es:
MARCELO BALLESTEROS, JOS\'E F. GIL, JUAN CARLOS ROSALES AND JUAN PABLO APARICIO
Lugar:
santiago
Reunión:
Simposio; BIOMAT 2011: International Symposium on Mathematical and Computational Biology; 2011
Institución organizadora:
BIOMAT consortium
Resumen:
Leishmaniasis is a vector-borne disease transmitted
by sandflies. Humans are incidental host unable to transmit the disease.
Persistence in the wild is due to a cycle involving sandfly transmission to
several species of rodents (reservoir hosts).
In this work we analyzed and used 20-year data on
cases of leishmaniasis and rainfall from San Ramon de la Nueva Oran, in Salta
Province, Argentina. Time series of human cases shown a non-stationary trend
and correlate with the rainfall series.
Records of human cases were used as a surrogate measure of the disease
dynamics in the wild.
We developed several individual-based models for the
host-vector system assuming random mixing among contacts between spatially
local host and vector populations. Using extensive numerical simulations we
computed several parameters describing disease dynamics as the Basic Reproductive
Number or epidemic size. Results were
used to select simple stochastic and deterministic population models. We show
that classical models using incidence rate proportional to the ratio vector to host
populations are the most adequate to describe the transmission process. We also
show that for populations sizes compatible with the random mixing assumption
stochastic effects dominates the dynamics, and therefore, larger population
dynamics should be described by metapopulation type models. We feed the model?s
parameters using the observed rainfall values. We also considered the observed
demographic growth. Human cases were
simulated assuming a constant exposure to the risk area. Model solutions show
both qualitative and quantitative agreement with reported cases.