INVESTIGADORES
APARICIO Juan Pablo
artículos
Título:
Transmission and dynamics of tuberculosis in generalized households
Autor/es:
JUAN P. APARICIO, ANGEL F. CAPURRO & CARLOS CASTILLO-CHAVEZ
Revista:
JOURNAL OF THEORETICAL BIOLOGY
Editorial:
Elsevier
Referencias:
Año: 2000 vol. 206 p. 327 - 341
ISSN:
0022-5193
Resumen:
Tuberculosis (TB) transmission is enhanced by systematic exposure to an infectious individual.This enhancement usually takes place at either the home, workplace, and/or school (generalizedhousehold). Typical epidemiological models do not incorporate the impact of generalizedhouseholds on the study of disease dynamics. Models that incorporate cluster (generalizedhousehold) effects and focus on their impact on TB's transmission dynamics are developed.Detailed models that consider the effect of casual infections, that is, those generated outsidea cluster, are also presented. We find expressions for the Basic Reproductive Number asa function of cluster size. The formula for R0 separates the contributions of cluster and casualinfections in the generation of secondary TB infections. Relationships between cluster andclassical epidemic models are discussed as well as the concept of critical cluster size.
