JNJ7777120 COMPOUND AMELIORATES DAMAGE IN SALIVARY GLANDS, GINGIVA AND PERIODONTAL BONE PRODUCED BY EXPERIMENTALLY INDUCED PERIODONTITIS IN RATS

JUAN P PRESTIFILIPPO; JAVIER FERNÁNDEZ-SOLARI; DIEGO MARTINEL LAMAS; CLAUDIA MOHN; ELENA S RIVERA; JUAN C ELVERDIN; VANINA A MEDINA

Congreso; European Histamine Research Society, XLII Annual Meeting; 2013

Periodontitis is a chronic disease caused by oral bacterial infection and persistent local inflammation, which results in alveolar bone resorption, soft tissue attachment injury and could lead to tooth loss. Recently, we have reported that histamine is able to reduce experimental periodontitis (EP)-induced damage on submandibular gland (SMG) and periodontal bone structure. This study investigates whether the H4R ligand, JNJ7777120 (J77), could prevent EP-induced histological, functional and inflammatory alterations in SMG, periodontal bone and gingiva. Bilateral EP was induced for two weeks by placing a cotton thread ligature around the neck of both first lower molars in anesthetized male rats. J77 treatment (10 mg/kg, s.c.) was started 5 days before the end of the experimental period. J77 treatment prevented EP-induced SMG histological damage, reducing vacuolization and apoptosis (2.1±0.8 vs. 70.3 ± 3.4 apoptotic cells per field, P