Bioevaluation of a 32P-patch, designed for the treatment of skin diseases

SALGUEIRO J; DURÁN H,; PALMIERI M; PIRCHIO R; MEDINA V; UGHETTI R; CROCI M; NICOLINI J; ZUBILLAGA M

NUCLEAR MEDICINE AND BIOLOGY

Oxford Pergamon Press

Lugar: New York; Año: 2008 vol. 35 p. 233 - 237

0969-8051

Objective: The objective of this study was to design and evaluate a 32P patch for the treatment of skin diseases. Materials and Methods: The patch was prepared from chromic phosphate 32P and silicone. Bioelimination and biodistribution in healthy and treated animals, and the therapeutic efficacy of two treatment schemes (single dose and fractionated dose) in an animal model of skin cancer were studied. Results: Based on the bioelimination and biodistribution studies, no leakage of 32P from the patch was observed. The treated tumors reduced their mean diameter compared to controls. The single-dose therapeutic scheme showed a higher number of complete and partial remissions compared to the fractionated scheme. These results were confirmed by histopathological analysis of the samples. Conclusion: The 32P patch was designed and produced according to specifications for the treatment of superficial lesions of the skin. Although the 32P patch is an open source, it behaves like a sealed one for use in brachytherapy treatments