INVESTIGADORES
MEDINA Vanina Araceli
artículos
Título:
Mitochondrial apoptotic pathways.
Autor/es:
MOHAMAD NORA; GUTIERREZ ALICIA; NUÑEZ MARIEL; COCCA CLAUDIA; MARTIN GABRIELA; CRICCO GRACIELA; MEDINA VANINA; RIVERA ELENA; BERGOC ROSA
Revista:
BIOCELL
Editorial:
Centro Regional de Investigaciones Científicas y Tecnológicas
Referencias:
Lugar: Argentina; Año: 2005 vol. 29 p. 149 - 161
ISSN:
0327-9545
Resumen:
Apoptosis or programmed cell death (PCD) is a physiological process characteristic of pluricellular organisms leading to self-destruction of the cell. It is therefore involved in development, homeostasis and host defense. However, a significant difference has been shown between mammalian cell apoptosis and non-mammalian cell apoptosis: mitochondria are implicated only in the former. Execution of PCD includes the release of several proapoptotic proteins from the intermembrane space of mitochondria. They could exert their actions through a caspase dependent as well as a caspase independent way. On the other hand, regulation of PCD is mainly given by the Bcl-2 family members, which are in turn essentially regulated by activation of death receptors and/or DNA damage. Nowadays, execution of apoptosis is better known than its regulation. Nevertheless, we are still far of a complete understanding of the apoptotic process.
