Possible effect of Roundup on Sertoli cell function

GORGA AGOSTINA; RINDONE GUSTAVO; SOBARZO CRISTIAN; CAMBEROS MARIA C; PELLIZZARI ELIANA H; RIERA M FERNANDA; GALARDO MARÍA N; MERONI SILVINA B

Congreso; LXIII Reunion Anual de la Sociedad Argentina de Investigación Clinica; 2018

During the last 50 years a progressive decrease in male reproductive function has been observed. Epidemiological and experimental studies suggest that one of the main causes is exposure to environmental toxicants. Some studies suggest that herbicides such as glyphosate (G) and/or its commercial formulation Roundup (R) alter reproductive function; however direct actions at testicular level and the possible molecular mechanisms involved are unknown. The objective of this work was to analyze the effect of G and R on Sertoli cell (SC) physiology. SC from 20-day old rats were used. Cultures were treated with G or R (100ppm). Results are expressed as mean±SD, n=3,*p