Enantioselective hydrogenation of ethyl pyruvate over ionic exchange resins supported catalyts

NICOLAS CARRARA; GUSTAVO MENDOW; JUAN BADANO; CECILIA LEDERHOS; CAROLINA BETTI; JULIANA MACCARRONE; CARLOS VERA; MONICA QUIROGA; DORIS POLLET RUIZ

Beijing

Congreso; 16th International Congress on Catalysis; 2016

Chinese Academy of Sciences

The synthesis of optically active compounds is of scientific and industrial interest, asymmetric synthesis being the most efficient route for the production of pure enantiomers. In this kind of reactions, traces of a chiral modiffier caninduce the preferential formation of a enantiomer . Enantioselective hydrogenations are of special interest, particularly in the pharmaceutical industry, because many products and intermediates are synthesized by this route.Traditional catalysts used in these reactions are based on noble metals and have high metal loading and demand a complex preparation. It is of interest to prepare improved new catalysts for these reactions. Catalysts based on ionexchange resins have many advantages, such as simple preparation procedures, easy metal complex anchoring, low solubility in common solvents and easy access due its high porous structure. In this work catalysts of Pd, Pt, Rhand Au supported on a styrene-divinylbenzene ion exchange resin were prepared. A screening of catalysts suitable for the enantioselective hydrogenation of ethyl pyruvate was made. The reaction scheme can be seen in Figure 1. Theeffect of the metal loading, metal particle size and nature of the chiral modiffier on the enantioselectivity were also studied.