Plasma retinoids concentration in Leptodactylus chaquensis (Amphibia: Leptodactylidae) from rice agroecosystems, Santa Fe province, Argentina.

TEGLIA C.M; ATTADEMO A.M.,; PELTZER P.,; GOICIECHEA H.C; LAJMANOVICH, R.C.,

CHEMOSPHERE

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2015 vol. 135 p. 24 - 30

0045-6535

Retinoids are known to regulate important processes such as differentiation, development, andembryogenesis of vertebrates: Alteration in endogenous retinoids concentration is linked with teratogeniceffects. Retinol (ROH), retinoid acid (RA), and isoform 13-Cis-retinoic acid (13-Cis-RA), in plasmaof a native adults frog, Leptodactylus chaquensis from a rice field (RF) and a forest (reference site; RS) weremeasured. ROH did not vary between treatment sites. RA and 13-Cis-RA activities were higher(93.7 ± 8.6 lgmL1 and 131.7 ± 11.4 lgmL1, respectively) in individuals collected from RF than in thosefrom RS (65.5 ± 8.6 lgmL1 and 92.2 ± 10.2 lgmL1, respectively). The ratios retinoic acid-retinol (RA/ROH) and 13-Cis-RA/ROH revealed significantly higher values in RF than in RS. RA and 13-Cis-RA concentrationsin plasma on wild amphibian?s species such as L. chaquensis would be suitable biomarkers of pesticideexposure in field monitoring. Finally, the mechanism of alteration in retinoid metabolites alterationshould be further explored both in larvae and adult, considering that the potential exposition and uptakecontaminants vary between the double lives of these vertebrates.