INVESTIGADORES
LAJMANOVICH Rafael Carlos
artículos
Título:
Micronucleus induction in erythrocytes of the Hyla pulchella tadpoles (Amphibia: Hylidae) exposed to insecticide endosulfan
Autor/es:
LAJMANOVICH R.C; M. CABAGNA; P.M. PELTZER; G.A. STRINGHINI; A.M. ATTADEMO.
Revista:
MUTATION RESEARCH. GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2005 p. 67 - 72
ISSN:
1383-5718
Resumen:
Endosulfan is a synthetic chlorinated and environmental genotoxic pesticide used worldwide for crop production.We used themicronucleus test in erythrocytes of Hyla pulchella tadpoles in order to develop an experimental model for detecting genotoxiceffects of the synthetic chlorinated cyclodiene endosulfan. The frequency of micronuclei was examined in blood smears obtainedfrom tadpoles exposed in vivo to three different concentrations 2.5, 5, and 10 g/l of the compound and fixed at two samplingtimes 48 and 96 h. As a positive control larvae were exposed to 40 mg/l of cyclophosphamide. Results obtained here demonstratedthe genotoxic effects of the commercial formulation endosulfan in the experimental model assayed.
