INVESTIGADORES
PEREZ FILGUEIRA Daniel Mariano
artículos
Título:
Dynamics and predictive potential of antibodies against insect-derived recombinant Leishmania infantum proteins during chemotherapy of naturally infected dogs
Autor/es:
TODOLI, FELICITAT; GALINDO, INMACULADA; GOMEZ-SEBASTIAN, SILVIA; PEREZ-FILGUEIRA, DANIEL; ESCRIBANO, J. A. M.; ALBEROLA, JORDI; RODRIGUEZ-CORTEZ, ALEHI
Revista:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Editorial:
AMER SOC TROP MED & HYGIENE
Referencias:
Año: 2010 vol. 82 p. 795 - 800
ISSN:
0002-9637
Resumen:
A predictive marker for the success treatment of canine leishmaniasis is
required for the application of a more rational therapy protocol, which
must improve the probability of cure and reduce Leishmania resistance
to drugs. We investigated the dynamics and predictive value of
antibodies against insect-derived recombinant L. infantum proteins
rKMPII and rTRYP by using an enzyme-linked immunosorbent assay with
retrospective serum samples from 36 dogs during treatment of canine
leishmaniasis. In the entire group of dogs, concentrations of antibodies
against rKMPII and rTRYP significantly decreased earlier than
concentrations of antibodies against crude total Leishmania antigen (one
versus six months), which suggested that the dynamics of antibodies
against recombinant proteins may be useful for assessing clinical
improvement after treatment. Interestingly, decreases in antibody
concentrations against rKMPII occurred earlier in disease-free dogs than
in dogs that remain clinically ill one year after beginning of
treatment, which suggested that these antibodies may be useful for
predicting disease-free survival one year after the beginning of therapy
against canine leishmaniasis.