The key role of cumulus cells in oocytes in vitro maturation protocols

NIKOLOFF N

FERTILITY AND STERILITY

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2021

0015-0282

The only strategy which can completely circumvent complications associated with conventional in vitro fertilization (IVF) is in vitro maturation (IVM) of oocytes. IVM can contribute to fertility preservation programmes, where time constraints and/or health risks limit the use of controlled ovarian hyperstimulation for IVF/intracytoplasmic sperm injection (ICSI) (1). There is a need to characterize competence in human oocytes because low maturation rates in IVM systems suggest that a considerable proportion of retrieved oocytes are still meiotically incompetent. Venturas et al., (2021) (2) showed that the assessment of CC clusters obtained from patients undergoing assisted reproductive technology treatment using fluorescence lifetime imaging microscopy (FLIM) could be a good strategy to predict oocyte quality. It is important to remark that this methods is non-invasive.