Probiotic lactobacilli in formulas and hygiene products for the health of the urogenital tract

NADER-MACÍAS MARÍA ELENA FÁTIMA; DE GREGORIO PRISCILLA ROMINA; SILVA JESSICA ALEJANDRA

Pharmacology Research & Perspectives

Wiley-Blackwell Publishing Ltd

Año: 2021

2052-1707

Lactobacilli are the predominant microorganisms of the healthy human vagina. A novelalternative for the prevention and treatment of female urogenital tract infections (UGTI)is the inclusion of these microorganisms as active pharmaceutical ingredients in probioticformulas, and more recently in female hygienic products. Probiotics are definedas ?live microorganisms that, when administered in adequate amounts, confer a healthbenefit on the host.? A list of requirements must be considered during the developmentof probiotic product/formula for the female urogenital tract (UGT). This reviewaims to resume the requirements, probiotic characteristics, and clinical trial applied todetermine the effect of probiotic and potentially probiotic strains on different woman?sphysiological and pathological conditions, and in preterm birth prevention. A revision offemale hygienic products available in the world market is included, together with novelstudies applying nanotechnology for Lactobacillus incorporation in hygienic products.Further studies and well-designedclinical trials are urgently required to complementthe current knowledge and applications of probiotics in the female UGT. The use ofprobiotic formulas and products will improve and restore the ecological equilibrium ofthe UGT microbiome to prevent and treat UGTI in women under different conditions.